OPLL: Ossification of the Posterior Longitudinal Ligament

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Among Japanese, in whom OPLL is a leading cause of myelopathy, causing ectopic bone formation in the paravertebral ligament, Maeda et al. Tanaka et al.

Ossification Posterior Longitudinal Ligament

The best evidence of linkage was detected near marker D21S on 21q Nakajima et al. They identified 6 susceptibility loci for OPLL: 20p Twy 'tiptoe' walking Yoshimura mouse is a naturally occurring mutant that exhibits ossification of the spinal ligaments similar to OPLL Yamazaki et al. The trait is inherited as an autosomal recessive with almost complete penetrance. Ossification of the spinal ligaments occurs spontaneously at about 6 weeks of age and progresses relentlessly, resulting in severe motor paresis of limbs.

The changes in the spinal ligaments closely resemble those of human OPLL. In the study of F2 progeny, Okawa et al.


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Okawa et al. To elucidate the genetic basis of OPLL, studies were undertaken of the ttw 'tiptoe walking'; previously designated twy mouse, a naturally occurring mutant that exhibits ossification of the spinal ligaments very similar to human OPLL. Using a positional candidate-gene approach, Okawa et al.

WikiGenes - OPLL - ossification of posterior longitudinal

This enzyme regulates soft-tissue calcification and bone mineralization by producing inorganic pyrophosphate, a major inhibitor of calcification. The accelerated bone formation characteristic of ttw mice was thought to result from dysfunction of Npps caused by predicted truncation of the gene product, resulting in the loss of more than one-third of the native protein. The results provided novel insights into the mechanism of ectopic ossification and the etiology of human OPLL.

Chen, X. Targeted next-generation sequencing reveals multiple deleterious variants in OPLL-associated genes. Note: Electronic Article. Firooznia, H. Calcification and ossification of posterior longitudinal ligament of spine: its role in secondary narrowing of spinal canal and cord compression.

References

State J. Horikoshi, T. A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine. Koga, H. Genetic mapping of ossification of the posterior longitudinal ligament of the spine. Maeda, S. Gender-specific haplotype association of collagen alpha-2 XI gene in ossification of the posterior longitudinal ligament of the spine.

Nakajima, M.


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    Atlantoaxial instability associated with single or multi-level cervical spondylotic myelopathy. Analysis on the basis of surgical treatment of seven patients. Is instability the nodal point of pathogenesis for both cervical spondylotic myelopathy and ossified posterior longitudinal ligament?

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    Neurol India ; Search Articles. How to cite this article: Goel A. Ossification of posterior longitudinal ligament and cervical spondylosis: Same cause - Same treatment. J Craniovert Jun Spine ; Search Pubmed for Goel A.


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